张明哲

5657威尼斯，副教授、硕士生导师（理学博士）

研究方向

1.寄主-病原分子互作机理研究

2.天然产物化学与生物合成

教学情况

本科生课程：《植物组织培养》、《生物化学》、《分子生物学》

教育经历

2002年6月毕业于中国人民解放军军需大学，农学学士；

2007年6月毕业于吉林大学，农学硕士；

2020年6月毕业于吉林大学，理学博士；

工作经历

2002/07–2004/08，中国人民解放军军需大学：干部、教师。

2004/08–至今    5657威尼斯：助教、讲师、副教授。

联系方式

电话：0431-87835432

E-mail : mzzhang@jlu.edu.cn

主持或参加科研项目及人才计划项目情况（按时间倒排序）

1. 国家自然科学基金面上项目：组蛋白去甲基化酶 BcJar1调控植物灰霉病菌发育及致病机理研究；(No. 31871913)，01/2019-12/2022，结题，项目负责人

2. 国家自然科学基金面上项目：抗灰霉菌天然产物的发现及智慧农药递送平台构建研究；(No. 32271530)，01/2023-12/2026，在研，主要参加人

   3、藤茶等植物源复方抑菌活性等功能产品技术开发：04/2020 -04/2023，项目负责人

   4、国家自然科学基金面上项目：基于基因组和化学大数据的植物内生真菌“隐形天然产物”挖掘；

   (No. 31870332）01/2019-12/2022，主要参加人

5、公益性行业（农业）科研专项，（No. 201303025），保护地果蔬灰霉病绿色防控技术研究与示范; 01/2013 -12/2017，结题，主要参加人

6、国家自然科学基金面上项目：玉米苗期低温胁迫下转录谱变化与DNA甲基化修饰变化的综合研究；(No. 31100192)，01/2012 -12/2014，主要参加人

7、吉林大学农学部青年科研启动基金：实用高效的蜡蚧轮枝菌新菌株的创制，01/2006 -12/2008，主持

编著

1、《基础生物学实验指导》，2013.05吉林大学出版社，并列主编

近年主要代表论著

1. Zhang MZ*, Sun CH, Liu Y, Feng HQ, Chang HW, Cao SN, Li GH, Yang S, Hou J, Zhu-Salzman K, Zhang H, Qin QM*, Transcriptome analysis and functional validation reveal a novel gene BcCGF1 that enhances fungal virulence by promoting infection-related development and host penetration, Molecular Plant Pathology, 2020,00:1–20. DOI: 10.1111/mpp.12934 (IF: 5.663 TOP)

2. Chao-Yi Wang, Chengguo Jia, Ming-Zhe Zhang, Song Yang, Jian-Chun Qin,* and Ying-Wei Yang*, A Lesion Microenvironment-Responsive Fungicide Nanoplatform for Crop Disease Prevention and Control, Advanced Healthcare Materials 2021(IF: 9.993)

3. Chao-Yi Wang, Xin-Yue Lou, Zhi Cai, Ming-Zhe Zhang, Chengguo Jia, Jian-Chun Qin,* and Ying-Wei Yang*, Supramolecular Nanoplatform Based on Mesoporous Silica Nanocarriers and Pillararene Nanogates for Fungus Control, ACS Applied Materials & Interfaces, 2021/01/11 08:51:00(IF: 9.229)

4. Hou J*, Feng HQ, Chang HW, Liu Y, Li GH, Yang S, Sun CH, Zhang MZ, Yuan Y, Sun J, Zhang H, Qin QM*, The H3K4 demethylase Jar1 orchestrates ROS production and expression of pathogenesis-related genes to facilitate Botrytis cinerea virulence, New Phytologist, 2020, 225: 930-947. (IF:10.151 TOP)

5. Song CG*, Yang J*, Zhang MZ*, Ding G, Jia CG*, Qin JC* and Guo LP*, Marine Natural Products: the Important Resource of Biological Insecticide, Chem. Biodiversity, 2021, 18, e2001020

6. Sun J, Sun CH, Chang HW, Yang S, Liu Y, Zhang MZ, et al. Cyclophilin BcCyp2 Regulates Infection-Related Development to Facilitate Virulence of the Gray Mold Fungus Botrytis cinerea. Int J Mol Sci. 2021, 22, 1694.

7. Xiao JL*, Zhang YX*, J CG*, Zhang MZ*, Chen W, Zhang YB, Li B, Wei DS, Wu G*, Du XL*and Qin JC*, Bioactivity of allelochemicals isolated from the roots of Echinacea purpurea L. Moench on Amaranthus viridis L., Portulaca oleracea L. and Microcystis aeruginosa, Allelopathy Journal, 2021, 52 (1):119-130

8. Wang HY*, Zhang MZ*, Han X*, Cong J*, Wang SQ, He SL, Wei DS, Zhang YB, Qin JC and Diego A. Sampeitro, Insecticidal and repellent efficacy of the essential oil from Lobularia maritima and trans-3-pentenenitrile against insect pests of stored grains, International Journal of Food Properties, 2020, 23:1, 1125-1135, DOI:10.1080/10942912.2020.1778723

9. Wang SQ*, He SL*, Zhang MZ*, Zhang YX, Wang QY Zhang CY, Liu TY, Liu B, Han JY*, Qin JC*, Sampietro Diego A, Chemical composition and allelopathic potential of essential oils from Eupatorium maculatum onLolium perenne L. and Echinochloa crusgalli L. Allelopathy J. 2020, DOI:10.26651/allelo.j/2020-49-1-1253

10. Yang SX*, Song CG*, Kuang Y, Liu B, Zhang YX, Zhang MZ, Zhang CY, Ding G* and Qin JC*, Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada, Molecules, 2020, 25, 1222; doi:10.3390/molecules25051222

11. He SL*, Wang DC*, Zhang YM*, Yang SX, Li X, Wei DS, Zhang MZ, Qin JC*, Chemical Components and Biological Activities of the Essential Oil from Traditional Medicinal Food, Euryale ferox Salisb., Seeds, Journal of Essential Oil Bearing Plants, 2019, DOI: 10.1080/0972060X.2019.1595165

12. Song CG*, L J, Wang HY, L X, L B, Zhang MZ, Shang XH, L H, Gao JM* and Qin JC*, New Derivatives from Microbial Transformation of ent-Kaur-16-en-19-oic Acid by Cunninghamella echinulate. Chem Biodivers, 2020, DOI: 10.1002/cbdv.202000178

13. Song CG*, D G, Wu G, Yang J, Zhang MZ, Wang HY, Wei DS, Qin JC and Guo LP, Identification of a Unique Azaphilone Produced by Chaetomium globosum Isolated from Polygonatum sibiricum, Chem. Biodivers, 2020, DOI: 10.1002/cbdv.201900744

14. Wei Y*, Li LH*, Hu WJ, Ju HY, Zhang MZ, Qin QM, Zhang SH, Li GH, Suppression of Rice Blast by Bacterial Strains Isolatedfrom Cultivated Soda Saline-Sodic Soils, Int. J. Environ. Res, 2020, 17, 5248; doi:10.3390/ijerph17145248

15. Liu Y*, Liu JK, Li GH, Zhang MZ, Zhang YY, Wang YY, Hou J, Yang S, Sun J, Qin QM*, A novel Botrytis cinerea-specific gene BcHBF1 enhances virulence of the grey mould fungus via promoting host penetration and invasive hyphal development, Molecular Plant Pathology, 2019, 20(5): 731-747. (IF5-yr: 4.96)

16. Liu JK*, Chang HW, Liu Y, Qin YH, Zhang MZ, Cao SN, Li LT, Li GH, Qin QM*, The key gluconeogenic gene PCK1 is crucial for virulence of Botrytis cinerea via initiating its conidial germination and host penetration. Environmental Microbiology, 2018, 20(5): 1794-1814. (IF5-yr: 5.965)

17. Cao SN*, Yuan, Y, Qin YH, Zhang MZ, de Figueiredo P, Li GH*, and Qin QM*; The pre-rRNA processing factor Nop53 regulates fungal development and pathogenesis via mediating production of reactive oxygen species. Environmental Microbiology, 2018, 20(4): 1531-1549. (IF5-yr: 5.965)

18. Yang SX, Liu B, Tang M, Yang J, , Kuang Y, Zhang MZ, Zhang CY, Wang CY, Qin, JC*, Guo LP*,2019, Extraction of flavonoids from Cyclocarya paliurus (Juglandaceae) Iljinskaja leaves using  ethanol/salt aqueous two-phase system coupled with ultrasonic. Journal of Food Processing and Preservation. Doi:10.1111/jfpp.14469.

19. Aseem Pandey, Lin FR, Feng XH, Allison Rice-Ficht, Feng HQ, Thomas A. Ficht, Ana L. Cabello, Zhang MZ, Luciana F. da Costa, Takao Iwawaki, Paul de Figueiredo and Qin QM* 2018, Activation of Host IRE1α-Dependent Signaling Axis Contributes the Intracellular Parasitism of Brucella melitensis. Frontiers in Cellular and Infection Microbiology. doi:10.3389/fcimb.2018.00103

20. Wang DC*. Zhang YM, Li, X, Pan HY, Chang, M. Zheng, T. Sun JZ. Qiu DR. Zhang MZ. Wei DS, Qin, JC, Potential allelopathic azaphilones produced by the endophytic Chaetomium globosum TY1 inhabited in Ginkgo biloba using the one strain-many compounds method. 2017, Nat Prod Res. DOI: 10.1080/14786419.2016.1217208

21. Qiu DR*, Wang DC, Yang SX, Zhang YM, Wei DS, Zhang MZ, Sun JZ, Cong J, Guo J, He SL, Qin, JC, 2016, Chemical constituents from the fruits of Rhus typhina L. and their chemotaxonomic significance. Biochemical Systematics and Ecology, 2016, DOI: 69, 261-265, doi:10.1016/j.bse.2016.10.011.

22. Qiu DR*, Wang DC, I.M. Chung, Zhang MZ, H.Cheng, Wei DS, Qin JC, Yang SX,

Allelopathic effects of essential oil of Hosta ventricosa flowers on seed germination and seedling growth of crops. 2015, Allelopathy J , DOI: 36, 103-108